Nineteen of Medvedev's twenty-one championships have been earned on hard courts
A resurgent the Russian player won his initial title for over two years with victory over Corentin Moutet in the competition championship match.
Medvedev, a former world number one, has endured a difficult year, achieving just a single victory at the major tournaments and undergoing a meltdown at the New York tournament.
The player's inconsistency on the tennis tour - and struggles with his service game in particular - resulted in him dropping out of the world's top 10 and ultimately splitting with long-term coach Cervara.
Now training with Thomas Johansson and Goetzke, he has steadily improved in the last few weeks - climaxing in a closely contested three-set victory over Frenchman Corentin Moutet.
It is Medvedev's initial title after the Rome competition and first on a hard court after that period of the previous year.
Victory also means Medvedev has secured 21 titles at 21 distinct events.
"This marks the first occasion I'm at a tournament with my children at once, so to win a trophy is especially meaningful," said world number 14 Daniil Medvedev.
"This title is in tribute of my child Victoria, because the maiden victory I achieved when my child my daughter was born was for her."
Medvedev, the 2021 US Open champion, had failed in his past six finals, including in Halle in the past months.
The player's counter-punching strategy and regular outbursts on the tennis court had caused observers to question if his ability to perform at the top level was over.
But the player has altered his approach in the past month, striving to approach the net and perform aggressively, reinforced by an improved serve.
The champion fought back from a disadvantage in the opening set against the tricky opponent, winning 4 of the concluding five games to go ahead.
Both players traded breaks in the second set before the Frenchman, attempting for his first tour championship, seized the initiative to create a final set.
Moutet rescued 4 early-game break points in a tight final set before the Russian broke to fifteen to serve for the match.
Appropriately, he clinched the win with a rally at the net area, with Moutet incapable to control a return after over two and a half hours.